Molecular cloning of a human dentin sialophosphoprotein gene
نویسندگان
چکیده
منابع مشابه
Molecular cloning of a human dentin sialophosphoprotein gene.
Dentin sialoprotein (DSP) and dentin phosphoprotein (DPP; phosphophoryn) are two principal dentin-specific non-collagenous proteins. DPP is extremely acidic and is rich in aspartic acid and serine. By virtue of this structure, DPP may bind large amounts of calcium and may facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals. The func...
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BACKGROUND We determined recently that dentin sialophosphoprotein (DSPP), a member of the SIBLING (Small integrin-binding ligand N-linked glycoproteins) family of phosphoglycoproteins, is highly upregulated in human oral squamous cell carcinomas (OSCCs) where upregulation is associated with tumor aggressiveness. To investigate the effects of DSPP-silencing on the tumorigenic profiles of the ora...
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متن کاملDentin glycoprotein: the protein in the middle of the dentin sialophosphoprotein chimera.
Dentin sialophosphoprotein (DSPP) is a major secretory product of odontoblasts and is critical for proper dentin formation. DSPP is believed to be processed into only two structural/functional domains: dentin sialoprotein (DSP) and dentin phosphoprotein (DPP). Here we report the isolation and characterization of a third domain of DSPP, designated dentin glycoprotein (DGP). DGP was isolated from...
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ژورنال
عنوان ژورنال: European Journal of Oral Sciences
سال: 2000
ISSN: 0909-8836,1600-0722
DOI: 10.1034/j.1600-0722.2000.00765.x